10,11-dehydro Curvularin

A natural mycotoxin

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库存: 现货

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1mg

￥1975.00

1580.00

- +
5mg

￥7812.00

6250.00

- +
10mg

￥13537.00

10830.00

- +

已选 0 种 0 瓶

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货号: ajci67968
CAS: 21178-57-4
别名: α,β-dehydro Curvularin
分子式: C16H18O5
分子量: 290.3
纯度: >98%
溶解度: 30mg/mL in DMSO, 30mg/mL in DMF, 10mg/mL in Ethanol
储存: Store at -20°C
库存: 现货

Background

10,11-Dehydrocurvularin is an antibiotic and a strong activator of the heat shock response, a conserved evolutionary mechanism that maintains protein homeostasis via the overexpression of heat shock factor 1 (HSF1) and various chaperones including heat shock protein 90 (Hsp90). 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity[1][2].

参考文献:
[1]. Xu Y, et al. Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus. Appl Environ Microbiol. 2013 Mar;79(6):2038-47.
[2]. Cochrane RV, et al. Comparison of 10,11-Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs. Chembiochem. 2015 Nov;16(17):2479-83.