15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester

A potential impurity of latanoprost

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库存: 现货

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数量
1mg

￥1212.00

970.00

- +
5mg

￥5450.00

4360.00

- +
10mg

￥9687.00

7750.00

- +
50mg

￥42000.00

33600.00

- +

已选 0 种 0 瓶

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货号: ajci68086
CAS: 130273-87-9
别名: 15<span class=\foreign\>epi</span> Bimatoprost isopropyl ester, 15(R)Bimatoprost isopropyl ester, 15(R)17phenyl trinor PGF2α isopropyl ester
分子式: C26H38O5
分子量: 430.6
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2α isopropyl ester is a potential impurity in most commercial preparations of the latanoprost bulk drug product. The IC50 values for the free acid forms of 15(S)-17-phenyl trinor PGF2α and 15(R)-17-phenyl trinor PGF2α were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 µg dose of 15(R)-17-phenyl trinor PGF2α caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.