16α-hydroxy Estrone

A hydroxylated metabolite of estrone

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库存: 现货

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1mg

￥1337.00

1070.00

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5mg

￥3987.00

3190.00

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10mg

￥6437.00

5150.00

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货号: ajci68142
CAS: 566-76-7
别名: 16ALPHA-羟基雌酚酮,16αOHE
分子式: C18H22O3
分子量: 286.4
纯度: >98%
溶解度: DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:5): 0.15 mg/ml,DMSO: 20 mg/ml
储存: Store at -20°C
库存: 现货

Background

The naturally-occurring estrogens are estrone , estradiol , and estriol . 16α-hydroxy Estrone (16α-OHE1) is a hydroxylated metabolite of E1 as well as an interconversion product with E2. E1 is 16α-hydroxylated by cytochrome P450 (CYP) isoforms, including CYP1A1, CYP3A5, CYP3A4, and CYP3A7, with CYP3A5 being breast-specific. 16α-OHE1 is sulphatized or glucuronidated before excretion. It is increased in rheumatoid arthritis and decreased by physical activity. Unlike the parent estrogens and other hydroxylated metabolites of E1, 16α-OHE1 binds covalently and persistently activates estrogen receptors. In addition, this metabolite increases cell proliferation and does not suppress TNF-α secretion, whereas other estrogen metabolites are not pro-proliferative and have marked effects on TNF-α secretion. The levels of 16α-OHE1 are increased in some forms of hormone therapy. Because hormone therapy increases breast cancer risk, 16α-OHE1 has been implicated as a risk factor for breast cancer, although supportive data remains elusive.