1-Octadecyl Lysophosphatidic Acid

A lysophosphatidic acid analog

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库存: 现货

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数量
500ug

￥362.00

290.00

- +
1mg

￥700.00

560.00

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5mg

￥2975.00

2380.00

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10mg

￥5162.00

4130.00

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货号: ajci68258
CAS: 52977-29-4
别名: 1Octadecyl LPA
分子式: C21H45O6P
分子量: 424.6
纯度: >98%
溶解度: DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml,Ethanol:PBS (pH 7.2) ((1:1): 0.5 mg/ml
储存: Store at -20°C
库存: 现货

Background

1-Octadecyl lysophosphatidic acid (1-octadecyl LPA) is a LPA analog containing stearic acid at the sn-1 position. LPA binds to one of five different G protein linked receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility. Alkyl ether-linked LPA derivatives have a higher platelet aggregating activity than the acyl derivatives, most likely stemming from an alkyl-specific LPA receptor. For example, 1-octadecyl LPA has a platelet aggregating EC50 value of 9 nM versus 1-octadecanoyl LPA which has an EC50 value of 177 nM.