A phospholipid
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1-Oleoyl-2-palmitoyl-sn-glycero-3-PC (OPPC) is a phospholipid containing oleic acid and palmitic acid at the sn-1 and sn-2 positions, respectively, that is found in biological membranes. [1]? It can be used in the generation of liposomes and other artificial membranes. [2][3][4] Artificial membranes containing OPPC have been used to study S. aureus α-toxin assembly and the effects of phytol on membranes, as well as for the characterization of phospholipase A2.
Reference:
[1]. Kuge, H., Akahori, K., Yagyu, K., et al. Functional compartmentalization of the plasma membrane of neurons by a unique acyl chain composition of phospholipids. J. Biol. Chem. 289(39), 26783-26793 (2014).
[2]. Tomita, T., Watanabe, M., and Yasuda, T. Influence of membrane fluidity on the assembly of Staphylococcus aureus α-toxin, a channel-forming protein, in liposome membrane. J. Biol. Chem. 267(19), 13391-13397 (1992).
[3]. Bayburt, T., Yu, B.-Z., Lin, H.-K., et al. Human nonpancreatic secreted phospholipase A2: Interfacial parameters, substrate specificities, and competitive inhibitors. Biochemistry 32(2), 573-582 (1993).
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