1-β-D-Glucosylsphingosine (d18:1)

A lysolipid derivative of glucocerebroside

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库存: 现货

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1mg

￥1700.00

1360.00

- +
5mg

￥5087.00

4070.00

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货号: ajci68344
CAS: 52050-17-6
别名: Glucosyl-C18-Sphingosine, Glucosylsphingosine (d18:1), 1-β-D-Glucosylsphingosine (synthetic)
分子式: C24H47NO7
分子量: 461.6
纯度: >98%
溶解度: Chloroform:Methanol (2:1): Soluble,Ethanol: Soluble,Methanol: Soluble
储存: Store at 2-8°C, protect from light
库存: 现货

Background

1-β-D-Glucosylsphingosine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucocerebrosides . They are formed when sphingosines undergo glucosidation by UDP-glucose. Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells at concentrations of 10 and 50 μM, respectively. They also decrease the activity of glucocerebrosidase in LA-N-2 cells in a dose-dependent manner. Glucosylsphingosine levels are elevated in patients with Gaucher's disease, both in the spleen (in types 1, 2, and 3) and brain (type 2 and 3); thus, glucosylsphingosine has been used as a key biomarker of the disease. This product is a fully synthetic 1-β-D-glucosylsphingosine.