2H-Cho-Arg (trifluoroacetate salt)

A steroid-based cationic lipid

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库存: 现货

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1mg

￥512.00

410.00

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5mg

￥1812.00

1450.00

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10mg

￥3087.00

2470.00

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货号: ajci68564
CAS: 1609010-59-4
别名:
分子式: C39H73N5O3?2CF3COO
分子量: 886.1
纯度: >98%
溶解度: DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
储存: Store at -20°C
库存: 现货

Background

2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection. It forms a complex with plasmid DNA (pDNA) and decreases pDNA migration in an electrophoretic mobility shift assay at +/- charge ratios of 4 or higher. 2H-Cho-Arg facilitates transfection of a luciferase gene into H1299 cells, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein , but not by inhibitors of clathrin- or micropinocytosis-mediated endocytosis. It induces cytotoxicity in H1299 cells (IC50 = 92.7 μg/ml).