3-Deazauridine

A nucleoside analog with anticancer activity

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5mg

￥287.00

230.00

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10mg

￥562.00

450.00

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25mg

￥1125.00

900.00

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50mg

￥1787.00

1430.00

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货号: ajci68762
CAS: 23205-42-7
别名: 4-羟基-1-Β-D-呋喃核糖苷-2(1H)吡啶酮,NSC 126849
分子式: C10H13NO6
分子量: 243.2
纯度: >98%
溶解度: 10mg/mL in DMSO, 16mg/mL in DMF
储存: Store at -20°C
库存: 现货

Background

3-Deazauridine is a nucleoside analog. [1]? It is converted intracellularly to 3-deazauridine triphosphate, which competitively inhibits cytidine triphosphate synthetase thereby inhibiting biosynthesis of the nucleic acid cytidine 5’-triphosphate (CTP). 3-Deazauridine inhibits the growth of L1210 leukemia cells when used at a concentration of 6 µM and dose-dependently reduces mortality in a mouse model of leukemia.[2]? It also enhances the incorporation of decitabine into DNA in HL-60 myeloid and MOLT-3 lymphoid leukemia cells when used at a concentration of 20 µM. 3-Deazauridine (100 or 150 mg/kg), when combined with decitabine, reduces mortality in an L1210 leukemia mouse model.[3]

Reference:
[1]. Moriconi, W.J., Slavik, M., and Taylor, S. 3-Deazauridine (NSC 126849): An interesting modulator of biochemical response. Invest New Drugs 4(1), 67-84 (1986).
[2]. Bloch, A., Dutschman, G., Currie, B.L., et al. Preparation and biological activity of various 3-deazapyrimidines and related nucleosides. J. Med. Chem. 16(3), 294-297 (1973).
[3]. Raynal, N.J.-M., Momparler, L.F., Rivard, G.E., et al. 3-Deazauridine enhances the antileukemic action of 5-aza-2'-deoxycytidine and targets drug-resistance due to deficiency in deoxycytidine kinase. Leuk. Res. 35(1), 110-118 (2011).