4'-Aminomethyl-4,5',8-trimethylpsoralen

A photoreactive nucleic acid crosslinking probe

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1mg

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5mg

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货号: ajci68920
CAS: 64358-50-5
别名: 4'-Aminomethyltrioxsalen
分子式: C15H15NO3
分子量: 257.3
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml,Ethanol: 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

4'-Aminomethyl-4,5',8-trimethylpsoralen is a bifunctional photoreactive agent for crosslinking nucleic acids. In the dark, it intercalates into double-stranded regions in DNA or RNA. Upon long wavelength UV irradiation (e.g., 365 nm), 4'-aminomethyl-4,5',8-trimethylpsoralen first forms a covalent monoadduct with a pyrimidine base, followed by covalently linking with an adjacent pyrimidine on the opposite strand. Short wavelength UV irradiation (e.g., 254 nm) reverses this reaction. 4'-Aminomethyl-4,5',8-trimethylpsoralen has a high binding affinity for RNA and has been used to study different types of RNA from diverse organisms, including viruses.