Amcinonide

A synthetic corticosteroid

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
50mg

￥450.00

360.00

- +
100mg

￥825.00

660.00

- +
250mg

￥1712.00

1370.00

- +
500mg

￥3200.00

2560.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci69806
CAS: 51022-69-6
别名: 安西奈德; CL-34699
分子式: C28H35FO7
分子量: 502.6
纯度: >98%
溶解度: DMF: 20 mg/ml,DMSO: 25 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml,Ethanol: 10 mg/ml
储存: Store at -20°C
库存: 现货

Background

Amcinonide inhibit NO release from activated microglia with IC50 3.38 nM. Amcinonide has affinity for the glucocorticoid receptor.IC50 value: 3.38 nM [1]Target: NO releasein vitro: Simultaneous immunofluorescent staining for T6 and Ia antigenicity within human epidermis of Amcinonide treated skin detected reduced numbers of T6+/Ia+ cells with a concomitant increase in T6+/Ia- cells. [2]in vivo: Amcinonide is an anti-inflammatory agent, elicites whitening of a few hairs in both pheomelanic and eumelanic mice. Amcinonide brings about a marked reduction in the numbers of DOPA-positive epidermal melanocytes inhabiting the tails of eumelanic or pheomelanic mice. Amcinonide exertes a deleterious influence on the structure and function of tail epidermis. [3]

参考文献:
[1]. Hong J, et al. Identification and characterization of triamcinolone acetonide, a microglial-activation inhibitor. Immunopharmacol Immunotoxicol. 2012 Dec;34(6):912-918.
[2]. Berman B, et al. Modulation of expression of epidermal Langerhans cell properties following in situ exposure to glucocorticosteroids. J Invest Dermatol. 1983 Mar;80(3):168-171.
[3]. Quevedo WC Jr, et al. Influence of depigmenting chemical agents on hair and skin color in yellow (pheomelanic) and black (eumelanic) mice. Pigment Cell Res.1990 Mar-Apr;3(2):71-79.