AUY954

A selective S1P1 receptor agonist

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库存: 现货

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数量
500ug

￥1012.00

810.00

- +
1mg

￥1925.00

1540.00

- +
5mg

￥6025.00

4820.00

- +

已选 0 种 0 瓶

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货号: ajci69996
CAS: 820240-77-5
别名:
分子式: C25H20F3NO2S
分子量: 455.5
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
储存: Store at -20°C
库存: 现货

Background

AUY954 is an orally bioavailable and selective agonist of the sphingosine-1-phosphate receptor 1 (S1P1; EC50 = 1.2 nM for stimulating GTPγS binding to S1P1 in CHO cells). It is highly selective for the S1P1 receptor with EC50 values of >10,000, 1,210, >1,000, and 340 nM for S1P2, S1P3, S1P4, and S1P5 receptors, respectively. AUY954 reduces circulating lymphocytes and prevents rejection of rat heart allografts. In a rat model of experimental autoimmune neuritis, chronic treatment with AUY954 (10 mg/kg), starting on the day of immunization, almost completely prevents peripheral paralysis. In the same model, it also decreases T cell, B cell, and macrophage infiltration and perivascular demyelination in sciatic nerves.