Cephaeline

An alkaloid with diverse biological activities

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库存: 现货

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1mg

￥2825.00

2260.00

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5mg

￥5487.00

4390.00

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货号: ajci70698
CAS: 483-17-0
别名: 吐根酚碱; (-)-Cephaeline; NSC 32944 free base
分子式: C28H38N2O4
分子量: 466.6
纯度: >98%
溶解度: Acetonitrile: slightly soluble,Chloroform: slightly soluble,Ethanol: slightly soluble,Methanol: slightly soluble
储存: 4°C, protect from light
库存: 现货

Background

Cephaeline is an alkaloid originally isolated from C. ipecacuanha with diverse biological activities. It inhibits the cytochrome P450 (CYP) isoforms CYP2D6 and CYP3A4 in vitro (Kis = 54 and 355 μM, respectively). Cephaeline reduces Zika virus (ZIKV) NS1 protein expression in HEK293 cells (IC50 = 26.4 nM) and reduces viral titer in ZIKV-infected SNB-19 cells (IC50 = 3.11 nM). In vivo, cephaeline (2 mg/kg, i.p.) reduces serum viral load in ZIKV-infected Ifnar1-/- mice. It induces emesis in ferrets when administered at a dose of 0.5 mg/kg, an effect that is prevented by the serotonin (5-HT) receptor subtype 5-HT3 antagonist ondansetron. Cephaeline (1 mg/kg) also increases output of respiratory tract fluid in rabbits.