安捷凯生物医药
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  • Cuspin-1
Cuspin-1的可视化放大

Cuspin-1

An upregulator of SMN protein

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Cuspin-1的二维码
  • 库存: 现货
可选规格
  • 包装
    价格
    促销价
    数量
  • 5mg
    ￥937.00
    750.00
    - +
  • 10mg
    ￥1587.00
    1270.00
    - +
  • 25mg
    ￥3500.00
    2800.00
    - +
  • 50mg
    ￥6462.00
    5170.00
    - +
已选 0 种 0 瓶
金额: ￥0.00
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使用我司产品发表的文章

  • 货号: ajci70906
  • CAS: 337932-29-3
  • 别名: Chemical Upregulator of SMN Protein-1
  • 分子式: C13H10BrNO
  • 分子量: 276.1
  • 纯度: >98%
  • 溶解度: DMF: 25 mg/mL,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 16 mg/mL,Ethanol: 1 mg/mL
  • 储存: Store at -20°C
  • 库存: 现货

Background

The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Decreases in SMN, typically a consequence of defects in the smn1 gene, result in the death of motor neurons and lead to the neurodegenerative disease, spinal muscular atrophy (SMA). Cuspin-1 is a small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA patient fibroblasts by 50% at 18 µM. Its mechanism of action is thought to involve increased phosphorylation of ERK to initiate Ras-Raf-MEK signaling, which results in an increased rate of SMN translation.

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