Daphnoretin

A coumarin with diverse biological activities

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1mg

￥550.00

440.00

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5mg

￥875.00

700.00

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10mg

￥1525.00

1220.00

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20mg

￥2500.00

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货号: ajci70996
CAS: 2034-69-7
别名: 西瑞香素,Dephnoretin; Thymelol
分子式: C19H12O7
分子量: 352.29
纯度: >98%
溶解度: DMF: 25 mg/ml,DMSO: 25 mg/ml,Ethanol: partially soluble,PBS (pH >10.2): Partially soluble
储存: 4°C, protect from light
库存: 现货

Background

Daphnoretin is a coumarin that has been found in W. indica and has diverse biological activities.^1,2,3 It induces aggregation of washed rabbit platelets (EC₅₀ = 17.2 μM), an effect that is reversed by the protein kinase C (PKC) inhibitor staurosporine .¹ Daphnoretin is active against respiratory syncytial virus (RSV) in a plaque reduction assay using HEp-2 cells (IC₅₀ = 5.87 μg/ml).² It halts the cell cycle at the G₂/M phase, induces apoptosis, and inhibits proliferation of human osteosarcoma (HOS) cells (IC₅₀ = 3.89 μM).³ Daphnoretin also reduces proliferation, invasion, and migration of HCT116 colon cancer cells in a concentration-dependent manner.⁴

1.Feng, N.K.O., Chang, Y.L., Kuo, Y.H., et al.Daphnoretin, a new protein kinase C activator isolated from Wikstroemia indica C.A. MeyBiochem J.295(Pt 1)321-327(1993) 2.Ho, W.-S., Xue, J.-Y., Sun, S.S.M., et al.Antiviral activity of daphnoretin isolated from Wikstroemia indicaPhytother. Res.24(5)657-661(2010) 3.Gu, S., and He, J.Daphnoretin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cellsMolecules17(1)598-612(2012) 4.Yu, S., Guo, H., Gao, X., et al.Daphnoretin: An invasion inhibitor and apoptosis accelerator for colon cancer cells by regulating the Akt signal pathwayBiomed. Pharmacother.1111013-1021(2019)