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Darinaparsin

A dimethylated arsenic linked to glutathione with anticancer activities

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Darinaparsin的二维码
  • 库存: 现货
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  • 包装
    价格
    促销价
    数量
  • 1mg
    ¥512.00
    410.00
    - +
  • 5mg
    ¥2187.00
    1750.00
    - +
  • 10mg
    ¥3625.00
    2900.00
    - +
  • 25mg
    ¥7062.00
    5650.00
    - +
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  • 货号: ajci71000
  • CAS: 69819-86-9
  • 别名: Dimethylarsinic glutathione
  • 分子式: C12H22AsN3O6S
  • 分子量: 411.3
  • 纯度: >98%
  • 溶解度: 0.1mg/mL in ethanol and DMF, 10mg/mL in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5-10 µM) and patient-derived primary prostate cancer cells (IC50s = 2.5-20 µM), as well as Jurkat T cell lymphoma and L540 Hodgkin lymphoma cells (IC50s = 2.7 and 1.3 µM, respectively). [1][2] It decreases the tumor-initiating subpopulation in DU145 and PC3 cells and halts the cell cycle in the G2/M phase. Darinaparsin decreases transcription of Gli-2, a transcription factor that mediates Sonic hedgehog signaling, when used at a concentration of 1.5 but not 3 µM. It decreases SHP1 phosphatase activity and increases ERK phosphorylation. [2] Darinaparsin reduces tumor growth in DU145 and PC3 prostate cancer mouse xenograft models when administered at a dose of 100 mg/kg every other day.[1]


Reference:
[1]. Bansal, N., Farley, N.J., Wu, L., et al. Darinaparsin inhibits prostate tumor-initiating cells and Du145 xenografts and is an inhibitor of hedgehog signaling. Mol. Cancer Ther. 14(1), 23-30 (2015).
[2]. Ravi, D., Bhalla, S., Gartenhaus, R.B., et al. The novel organic arsenical darinaparsin induces MAPK-mediated and SHP1-dependent cell death in T-cell lymphoma and Hodgkin lymphoma cells and human xenograft models. Clin. Cancer Res. 20(23), 6023-6033 (2014).

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