DDD85646

An inhibitor of T. brucei N-myristoyltransferase

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥1337.00

1070.00

- +
5mg

￥4212.00

3370.00

- +
10mg

￥6550.00

5240.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

Background

DDD85646 is a moderately bioavailable pyrazole sulphonamide inhibitor of T. brucei N-myristoyltransferase (TbNMT) with an apparent Ki value of 1.44 nM.1 T. brucei is the parasite responsible for human African trypanosomiasis (HAT), also known as African sleeping sickness, and is transmitted through the tsetse fly. DDD85646 administration in mice (12.5 mg/kg for four days) ameliorated T. brucei in an acute mouse model of HAT.[1] It less potently inhibits growth of T. cruzi (EC50 = 6.9 μM).

Reference:
1. Frearson, J.A., Brand, S., McElroy, S.P., et al. N-myristoyltransferase inhibitors as new leads to treat sleeping sickness. Nature 464(7829), 728-732 (2010).