Demethylwedelolactone

A coumestan with diverse biological activities

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1mg

￥575.00

460.00

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5mg

￥1737.00

1390.00

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10mg

￥2825.00

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货号: ajci71056
CAS: 6468-55-9
别名: 去甲蟛蜞菊内酯
分子式: C15H8O7
分子量: 300.22
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 20 mg/ml
储存: Store at -20°C
库存: 现货

Background

Demethylwedelolactone (DWL) is a coumestan, originally isolated from E. alba, with diverse biological activities.^1,2,3,4 It reduces cytotoxicity induced by CCL₄ and galactosamine in rat hepatocytes in a dose-dependent manner.¹ DWL inhibits trypsin with an IC₅₀ value of 3.0 μg/ml in vitro.² It is the major constituent in purified butanolic extracts of E. prostrata which inhibit lethal and hemorrhagic activities of C. rhodostoma venom.³ DWL also inhibits anchorage-independent cell growth of MDA-MB-231 breast cancer cells and decreases the number of lung metastases in an MDA-MB-231 xenograft model in nude mice.⁴

1.Wagner, H., Geyer, B., Kiso, Y., et al.Coumestans as the main active principles of the liver drugs Eclipta alba and Wedelia calendulaceaPlanta Med.5370-374(1986) 2.Syed, S.D., Deepak, M., Yogisha, S., et al.Trypsin inhibitory effect of wedelolactone and demethylwedelolactonePhytother. Res.17(4)420-421(2003) 3.Pithayanukul, P., Laovachirasuwan, S., Bavovada, R., et al.Anti-venom potential of butanolic extract of Eclipta prostrata against Malayan pit viper venomJ. Ethnaopharmacol.90(2-3)347-352(2004) 4.Lee, Y.-J., Lin, W.-L., Chen, N.-F., et al.Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude miceEur. J. Med. Chem.56(1)631-637(2012)