Disuccinimidyl Sulfoxide

A protein cross-linking probe with collision-induced dissociation-cleavable sites

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库存: 现货

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50mg

￥662.00

530.00

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100mg

￥1275.00

1020.00

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250mg

￥2850.00

2280.00

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500mg

￥4650.00

3720.00

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货号: ajci71204
CAS: 1351828-03-9
别名: DSSO
分子式: C14H16N2O9S
分子量: 388.3
纯度: >98%
溶解度: DMF: 10 mg/ml DMSO: 20 mg/ml DMSO:PBS (pH 7.2)(1:5): 0.15 mg/ml
储存: Store at -20°C
库存: 现货

Background

Disuccinimidyl sulfoxide (DSSO) is a protein cross-linking probe designed to be used with mass spectrometry (MS). It contains two symmetric collision-induced dissociation (CID)-cleavable sites that allow effective identification of DSSO-cross-linked peptides based on their distinct fragmentation patterns. [1] The CID-induced separation of interlinked peptides in MS/MS permits MS3 analysis of single peptide chain fragment ions with defined modifications, due to DSSO remnants, for easy interpretation and unambiguous identification using existing database searching tools.[1]

Reference:
[1]. Kao, A., Chiu, C.-l., Vellucci, D., et al. Development of a novel cross-linking strategy for fast and accurate identification of cross-linked peptides of protein complexes. Mol. Cell. Proteomics 10(1), (2011).