DL-Glyceraldehyde-3-phosphate

DL-甘油醛-3-磷酸天冬氨酸氨基转移酶阳离子和阴离子同工酶的一种时间依赖性抑制剂。.

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Background

DL-Glyceraldehyde 3-phosphate is a time-dependent inhibitor of the cationic and anionic isozymes of aspartate aminotransferase[1]. DL-Glyceraldehyde-3-phosphate, as an intermediate in several metabolic pathways, can be derived from fructose 1,6-bisphosphate by fructose bisphosphate aldolase in a reaction that also produces dihydroxyacetone phosphate (DHAP). It is processed to 1,3-bisphosphoglycerate by glyceraldehyde phosphate dehydrogenase and NAD^+[2].

In vitro, DL-glyceraldehyde 3-phosphate has inhibition on the pyridoxamine form of the cationic isozyme with Ki of 0.084 mM. DL-glyceraldehyde 3-phosphate has inhibition on the pyridoxamine form of the anionic isozyme with Ki of 0.39 mM[2]. At a concentration of 2.5 mM, DL-glyceraldehyde 3-phosphate has a bactericidal effect upon Escherichia coli[3].

In vivo, phosphatidylethanolamine and phosphatidylglycerol accumulation are inhibited to the same extent by the addition of DL-glyceraldehyde 3-phosphate to a culture of E. coli[3].

参考文献:
[1]Kopelovich L, et al. Kinetics of the inhibition of aspartate aminotransferase isozymes by DL-glyceraldehyde 3-phosphate. Eur J Biochem. 1971 Jun 11;20(3):351-62.
[2]Song J, et al. The Multiple Roles of Glucose-6-Phosphate Dehydrogenase in Tumorigenesis and Cancer Chemoresistance. Life (Basel). 2022 Feb 12;12(2):271.
[3] Tang CT, et al. L-Glyceraldehude 3-phosphate, a bactericidal agent. Antimicrob Agents Chemother. 1977 Jan;11(1):147-53.

DL-甘油醛-3-磷酸是冬氨酸氨基转移酶阳离子和阴离子同工酶的一种时间依赖性抑制剂[1]。DL-甘油醛-3-磷酸作为多种代谢途径的中间产物,可通过果糖二磷酸醛缩酶从 1,6-二磷酸果糖中提取,在反应中还会产生磷酸二羟丙酮(DHAP)。在磷酸甘油醛脱氢酶和 NAD+ 的作用下,它被加工成 1,3-二磷酸甘油酯[2]。

在体外,DL-甘油醛-3-磷酸对阳离子同工酶的吡多胺形式具有抑制作用,Ki 为 0.084 mM。DL-甘油醛-3-磷酸对阴离子同工酶的吡多胺形式有抑制作用,Ki 为 0.39 mM[2]。2.5 毫摩尔浓度的DL-甘油醛-3-磷酸对大肠杆菌有杀菌作用[3]。

在大肠杆菌培养物中加入 DL-甘油醛-3-磷酸,可在相同程度上抑制磷脂酰乙醇胺和磷脂酰甘油的积累[3]。