Erucin

An isothiocyanate with neuroprotective and antioxidant effects

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库存: 现货

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10mg

￥612.00

490.00

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25mg

￥1225.00

980.00

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50mg

￥2012.00

1610.00

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货号: ajci71492
CAS: 4430-36-8
别名: 芥酸精；甘油三芥酸酯
分子式: C6H11NS2
分子量: 161.3
纯度: >98%
溶解度: 16mg/mL in ehanol, 14mg/mL in DMSO, 12mg/mL in DMF
储存: Store at -20°C
库存: 现货

Background

Erucin is an isothiocyanate derived from glucoerucin, a glucosinolate predominant in arugula (Eruca sativa Mill.) and other cruciferous vegetables. At 2.5-5 μM erucin can induce significant neuroprotective and antioxidant effects, increasing both total glutathione levels and total antioxidant capacity at the cytosolic level in dopaminergic-like neuroblastoma SH-SY5Y cells.[1] Growth inhibition, cell cycle regulation, apoptosis, and induction of detoxification enzymes have all been reported from use of erucin in prostate, lung, liver, and colon cancer cells.[2][3]

Reference:
[1]. Tarozzi, A., Morroni, F., Bolondi, C., et al. Neuroprotective effects of erucin against 6-hydroxydopamine-induced oxidative damage in a dopaminergic-like neuroblastoma cell line. International Journal of Molecular Sciences 13, 10899-10910 (2012).
[2]. Melchini, A., and Traka, M.H. Biological profile of erucin: A new promising anticancer agent from cruciferous vegetables. Toxins 2, 593-612 (2010).
[3]. Zhang, Y., Talalay, P., Cho, C.G., et al. A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure. Proceedings of the National Academy of Sciences of the United States of America 89, 2399-2403 (1992).