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  • F-Amidine (trifluoroacetate salt)
F-Amidine (trifluoroacetate salt)的可视化放大

F-Amidine (trifluoroacetate salt)

A PAD inhibitor

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F-Amidine (trifluoroacetate salt)的二维码
  • 库存: 现货
可选规格
  • 包装
    价格
    促销价
    数量
  • 100ug
    ￥512.00
    410.00
    - +
  • 250ug
    ￥1212.00
    970.00
    - +
  • 500ug
    ￥2337.00
    1870.00
    - +
  • 1mg
    ￥4100.00
    3280.00
    - +
已选 0 种 0 瓶
金额: ￥0.00
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使用我司产品发表的文章

  • 货号: ajci71544
  • CAS: 877617-46-4
  • 别名:
  • 分子式: C14H19FN4O2?CF3COOH
  • 分子量: 408.4
  • 纯度: >98%
  • 溶解度: DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

F-amidine is an inhibitor of protein arginine deiminases (PADs) that is selective for PAD1 and PAD4 (IC50s = 29.5, 350, and 21.6 µM for PAD1, PAD3, and PAD4 in vitro, respectively). It irreversibly inactivates all four PAD subtypes (kinact/KI = 2,800, 380, 170, and 3,000 M-1min-1 by covalently modifying an active site cysteine that is important for its catalytic activity. F-amidine is cytotoxic to HL-60, MCF-7, and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively).

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