FK-409

A nitric oxide donor

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库存: 现货

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1mg

￥300.00

240.00

- +
5mg

￥1400.00

1120.00

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10mg

￥2475.00

1980.00

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50mg

￥10787.00

8630.00

- +

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货号: ajci71580
CAS: 138472-01-2
别名: NOR-3
分子式: C8H13N3O4
分子量: 215.2
纯度: >98%
溶解度: 20mg/mL in DMSO, 34mg/mL in DMF, 36mg/mL in Ethanol
储存: Store at -20°C
库存: 现货

Background

FK-409 is a NO donor. It liberates NO in a time-dependent manner with a half-life of approximately 40 minutes in phosphate buffer (pH 7.4) at 37°C. [1] The IC50 for the inhibition of platelet aggregation is 4.9 µM. [2]

Reference:
[1]. Kita, Y., Hirasawa, Y., Maeda, K., et al. Spontaneous nitric oxide release accounts for the potent pharmacological actions of FK409. European Journal of Pharmacology 257, 123-130 (1994).
[2]. Fukuyama, S., Hirasawa, Y., Kato, Y., et al. Structure-activity relationships of spontaneous nitric oxide releasers, FK409 and its derivatives. Journal of Pharmacology and Experimental Therapeutics 282, 236-242 (1997).