Ganglioside GD3 Mixture (sodium salt)

A mixture of ganglioside GD3

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库存: 现货

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促销价

数量
500ug

￥3212.00

2570.00

- +
1mg

￥5412.00

4330.00

- +

已选 0 种 0 瓶

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货号: ajci71700
CAS: 62010-37-1
别名: 双唾液酸神经节苷脂GD3
分子式: C70H123N3O29?2Na (for Sphingosine C18:1)
分子量: 1516.7
纯度: >98%
溶解度: Chloroform:Methanol (1:1): Soluble,Water: Soluble
储存: Store at -20°C
库存: 现货

Background

Ganglioside GD3 is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases. It induces apoptosis in HuT-78 cutaneous T cell lymphoma cells in a concentration-dependent manner and disrupts the mitochondrial membrane potential when used at a concentration of 200 μM. Expression of ganglioside GD3 in GD3-negative SK-MEL-28-N1 malignant melanoma cells increases both cell proliferation and invasion in vitro. Ganglioside GD3-deficient adult mice exhibit progressive loss of the neural stem cell (NSC) pool and impaired neurogenesis. Ganglioside GD3 mixture contains ganglioside GD3 molecular species with C18:1 and C20:1 sphingoid backbones.