Ganglioside GM3 Mixture (sodium salt)

A mixture of ganglioside GM3

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库存: 现货

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1mg

￥4000.00

3200.00

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货号: ajci71706
CAS: 54827-14-4
别名: 单唾液神经节苷酯GM3
分子式: C59H107N2O21?Na (for Sphingosine C18:1)
分子量: 1180.5
纯度: >98%
溶解度: Water: Soluble
储存: Store at -20°C
库存: 现货

Background

Ganglioside GM3 is a monosialoganglioside that demonstrates antiproliferative and proapoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation. It suppresses angiogenesis and reduces proliferation and migration of human umbilical vein endothelial cells (HUVECs) when used at a concentration of 20 μM via inhibition of VEGFR2 and Akt phosphorylation. Ganglioside GM3 induces dissociation of the insulin receptor-caveolin-1 complex from lipid microdomains, functioning as an inhibitor of insulin signaling and contributing to insulin resistance in adipocytes. Ganglioside GM3 mixture contains ganglioside GM3 molecular species with C18:1 and C20:1 fatty acyl chains.