A vitamin K2 analog
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Menaquinone 9 (MK-9) is a vitamin K2 analog that has been found in various bacteria, including E. coli. MK-9 is UV-sensitive and binds to soluble nitrate reductase, a component of the bacterial electron transport chain. In vivo, MK-9 increases plasma prothrombin concentration in vitamin K-deficient rats.
Reference:
[1]. Craciun, A.M., Groenen-van Dooren, M.M., Thijssen, H.H., et al. Induction of prothrombin synthesis by K-vitamins compared in vitamin K-deficient and in brodifacoum-treated rats. Biochim. Biophys. Acta. 1380(1), 75-81 (1998).
[2]. Brito, F., DeMoss, J.A., and Dubourdieu, M. Isolation and identification of menaquinone-9 from purified nitrate reductase of Escherichia coli. Journal of Bacteriology 177(13), 3728-3735 (1995).
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