Methylcarbamyl PAF C-16

A stable analog of PAF C-16

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库存: 现货

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1mg

￥575.00

460.00

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5mg

￥2600.00

2080.00

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10mg

￥4612.00

3690.00

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25mg

￥9237.00

7390.00

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货号: ajci72602
CAS: 91575-58-5
别名:
分子式: C26H55N2O7P
分子量: 538.7
纯度: >98%
溶解度: DMF: >25 mg/ml,DMSO: >25 mg/ml,Ethanol: >50 mg/ml,PBS pH 7.2: >25 mg/ml
储存: Store at -20°C
库存: 现货

Background

Methylcarbamyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH. It is nearly equipotent with PAF C-16 in its ability to induce platelet aggregation both in isolated platelets and in platelet-rich plasma. In NRK-49 cells overexpressing the PAF receptor, both PAF C-16 and methylcarbamyl PAF C-16 cause the induction of c-myc and c-fos and the activation of mitogen-activated protein kinase. Methylcarbamyl PAF C-16 induces G1 phase cell cycle arrest, suggesting a potential role for PAF in the inhibition of oncogenic transformation.