Mitomycin A

A bacterial metabolite

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库存: 现货

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数量
500ug

￥1150.00

920.00

- +
1mg

￥2037.00

1630.00

- +
5mg

￥9025.00

7220.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci72642
CAS: 4055-39-4
别名: 丝裂霉素A
分子式: C16H19N3O6
分子量: 349.3
纯度: >98%
溶解度: Chloroform: Slightly soluble,Methanol: Slightly soluble
储存: Store at -20°C
库存: 现货

Background

Mitomycin A is a bacterial metabolite originally isolated from S. caespitosus. It reduces migration inhibition factor (MIF) production by isolated human lymphocytes when used at a concentration of 0.25 µg/ml and decreases spontaneous migration of WEHI-3 murine monocytes when used at concentrations of 0.5 and 5 µg/ml. Mitomycin A forms intra- and interstrand adducts with DNA in the presence of thiols, such as dithiothreitol (DTT). It reduces tumor growth in P388 leukemia and B16 melanoma mouse models with a minimum effective dose (MED) of 0.05 mg/kg for both but is toxic to mice with an LD50 value of 2 mg/kg.