ML-162

A GPX4 inhibitor

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库存: 现货

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数量
5mg

￥937.00

750.00

- +
10mg

￥1437.00

1150.00

- +
25mg

￥3050.00

2440.00

- +
50mg

￥4862.00

3890.00

- +
100mg

￥7800.00

6240.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci72670
CAS: 1035072-16-2
别名:
分子式: C23H22Cl2N2O3S
分子量: 477.4
纯度: >98%
溶解度: 1mg/mL in ethanol, 25mg/ml in DMSO, 10mg/mL in DMF
储存: Store at -20°C
库存: 现货

Background

ML-162 is a GPX4 inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).[1],[2] It shares a similar structure but is more potent and selective than (1S,3R)-RSL3, a previously reported inhibitor of RAS oncogene-expressing cells.[2]

Reference:
[1]. Yang, W.S., and Stockwell, B.R. Ferroptosis: Death by lipid peroxidation. Trends Cell Biol. 26(3), 165-176 (2016).
[2]. We?wer, M., Bittker, J.A., Lewis, T.A., et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg. Med. Chem. Lett. 22(4), 1822-1826 (2012).