N-Docosanoyl Taurine

A FAAH substrate discovered during metabolite profiling

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1mg

￥1375.00

1100.00

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5mg

￥6200.00

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10mg

￥11012.00

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货号: ajci72950
CAS: 783284-48-0
别名:
分子式: C24H49NO4S
分子量: 447.7
纯度: >98%
溶解度: DMF: 5 mg/ml,DMSO: 10 mg/ml,PBS (pH 7.2): 0.25 mg/ml
储存: Store at -20°C
库存: 现货

Background

Several different arachidonoyl amino acid conjugates, including N-arachidonoyl dopamine and N-arachidonoyl-L-serine, have been isolated and characterized from bovine brain. N-Docosanoyl taurine is one of several novel taurine-conjugated fatty acids discovered during mass spectrometry lipidomic analysis of brain and spinal cord from wild-type and fatty acid amide hydrolase (FAAH) knockout mice. The levels of N-docosanoyl taurine were elevated ~12 fold in FAAH-/- mice compared to wild-type mice, indicating that FAAH utilizes N-docosanoyl taurine as a substrate. However, in vitro experiments with purified FAAH indicate that related N-fatty acyl taurines and ethanolamines of similar chain length are hydrolyzed 2,000-50,000 times more slowly by FAAH compared to oleoyl ethanolamide. N-acyl taurines bearing polyunsaturated acyl chains can activate members of the transient receptor potential (TRP) family of calcium channels, including TRPV1 and TRPV4.