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安捷凯生物医药，安捷凯化学
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  2. Calcium Channel
  3. Nemadipine A
  • Nemadipine A
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Nemadipine A

An L-type calcium channel blocker

原价
￥1150-9600
价格
￥ 920-7680
Nemadipine A的二维码

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  • 库存: 现货
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  • 货号: ajci72964
  • CAS: 54280-71-6
  • 别名:
  • 分子式: C19H18F5NO4
  • 分子量: 419.3
  • 纯度: >98%
  • 溶解度: DMSO: 20 mg/ml,Ethanol: 15 mg/ml,Methanol: 100 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in the C. elegans genome. It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells. It also decreases Survivin expression when used alone or in combination with TRAIL in A549 cells.

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