Nocloprost

A gastoprotective PGE2 analog

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
500ug

￥2012.00

1610.00

- +
1mg

￥3812.00

3050.00

- +
5mg

￥15937.00

12750.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci73108
CAS: 79360-43-3
别名: 诺氯前列素
分子式: C22H37ClO4
分子量: 401
纯度: >98%
溶解度: DMF: 11 mg/ml,DMSO: 10 mg/ml,Ethanol: 16 mg/ml,Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
储存: Store at -20°C
库存: 现货

Background

Nocloprost is a stable prostaglandin E2 analog with gastroprotective and ulcer-healing properties. As a weak acid (pKa = 5), it accumulates in the gastric mucosa at low pH and can prevent the formation of gastric lesions in rats when administered intragastrically 30 minutes before 100% ethanol, acidified aspirin, acidified taurocholate, water immersion, or restraint stress (ID50s = 0.25, 0.58, 0.06 and 0.12 μg/kg, respectively). Additionally, nocloprost has been used to inhibit evoked acetylcholine release from isolated human bronchi (IC50 = 4 nM) to study factors that regulate human airway smooth muscle tone and secretion.