Oleoyl 3-carbacyclic Phosphatidic Acid

Inhibitor of autotaxin, antagonist of LPA1 and LPA3

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库存: 现货

可选规格

包装

价格

促销价

数量
500ug

￥1250.00

1000.00

- +
1mg

￥2400.00

1920.00

- +
5mg

￥10025.00

8020.00

- +
10mg

￥17350.00

13880.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

Cyclic phosphatidic acids (cPAs) are naturally occurring analogs of lysophosphatidic acid (LPA) in which the sn-2 hydroxy group forms a 5-membered ring with the sn-3 phosphate. Carba-derivatives of cPA (ccPA) are modified at the sn-2 (2-ccPA) or sn-3 (3-ccPA) linkage, preventing the opening of cPA to produce lysophosphatidic acid (LPA). Oleoyl 3-Carbacyclic Phosphatidic Acid (3-ccPA 18:1) is a cyclic LPA analog that contains the 18:1 fatty acid, oleate, at the sn-1 position of the glycerol backbone. At 25 μM, it inhibits the transcellular migration of MM1 cells across mesothelial cell monolayers in response to fetal bovine serum (90.1%) or LPA (99.9%) without affecting proliferation. 3-ccPA 18:1, at 0.1-1.0 μM, significantly inhibits autotaxin, an enzyme that is important in cancer cell survival, growth, migration, invasion, and metastasis.