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PCTR1的可视化放大

PCTR1

A specialized pro-resolving mediator

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PCTR1的二维码
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  • 货号: ajci73400
  • CAS: 1810710-59-8
  • 别名: Protein Conjugates in Tissue Regeneration 1
  • 分子式: C32H47N3O9S
  • 分子量: 649.8
  • 纯度: >98%
  • 溶解度: DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 1 mg/ml,Ethanol/H20 (95:5): 2 mg/ml,PBS (pH 7.2): 0.1 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Protectin conjugates in tissue regeneration 1 (PCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is then converted to PCTR1 by glutathione S-transferase. PCTR1 levels increase during resolution of acute microbial-induced peritonitis in mice. PCTR1 (30 ng, i.p.) administration 12 hours post-infection increases macrophage numbers and activity and shortens the resolution phase of inflammation by 57%. It also reduces the levels of PGE2 , PGD2 , and TXB2 in peritoneal exudates.

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