PQ-10

A selective PDE10 inhibitor

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库存: 现货

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1mg

￥425.00

340.00

- +
5mg

￥1225.00

980.00

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10mg

￥1975.00

1580.00

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25mg

￥4262.00

3410.00

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货号: ajci73588
CAS: 927691-21-2
别名: 6,7-二甲氧基-4-[(3R)-3-(2-喹喔啉基氧基)-1-吡咯烷基]喹唑啉
分子式: C22H21N5O3
分子量: 403.4
纯度: >98%
溶解度: DMF: 25 mg/mL,DMF:PBS (pH 7.2) (1:20): 0.04 mg/mL,DMSO: 16 mg/mL
储存: Store at -20°C
库存: 现货

Background

PQ-10 is a potent and selective inhibitor of phosphodiesterase type 10 (PDE10; Ki = 4 nM). It has >38-fold selectivity for PDE10 over a panel of 60 CNS-associated receptors, enzymes, and ion channels in vitro. Subcutaneous injection of PQ-10 (32 mg/kg) leads to increases in striatal cGMP and phosphorylation of cAMP response element binding protein (CREB) in murine striatum, known markers of in vivo PDE10 inhibition. PQ-10 at a dose of 0.3 mg/kg, p.o., reduces scopolamine- and MK-801-induced memory deficits in rats. PQ-10 also inhibits tumor cell growth with IC50 values of 0.29 and 0.22 mM for HCT116 and SW480 colon cancer cells, respectively.