Prostaglandin F2α ethyl amide

An ocular hypotensive prodrug

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库存: 现货

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1mg

￥875.00

700.00

- +
5mg

￥3875.00

3100.00

- +
10mg

￥6900.00

5520.00

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货号: ajci73688
CAS: 54130-36-8
别名: Dinoprost ethyl amide, PGF2αNEt
分子式: C22H39NO4
分子量: 381.6
纯度: >98%
溶解度: DMF: 33mg/ml,DMSO: 16 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 300 μ g/ml
储存: Store at -20°C
库存: 现货

Background

Prostaglandin F2α ethyl amide (PGF2α-NEt) is an analog of PGF2α in which the C-1 carboxyl group has been modified to an N-ethyl amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that PG ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 µg/g corneal tissue/hr. PGF2α-NEt would be expected to show the typical intraocular effects of PGF2α free acid, but with the much slower hydrolysis pharmacokinetics of the PG N-amides.