Reduced Haloperidol

An active metobolite of haloperidol

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库存: 现货

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5mg

￥1012.00

810.00

- +
10mg

￥1925.00

1540.00

- +
25mg

￥4262.00

3410.00

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50mg

￥8050.00

6440.00

- +

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货号: ajci73862
CAS: 34104-67-1
别名: 还原氟哌啶醇
分子式: C21H25ClFNO2
分子量: 377.9
纯度: >98%
溶解度: Dichloromethane: slightly soluble,Methanol: slightly soluble
储存: Store at -20°C
库存: 现货

Background

Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4 and 31 nM, respectively) and stimulates brain-derived neurotrophic factor (BDNF) secretion from CCF-SSTG1 and U87MG astrocytic glial cells. It also inhibits norepinephrine, dopamine, and serotonin (5-HT) reuptake (Kis = 21, 25, and 33 μM, respectively, in COS-7 cells expressing the human transporters). Reduced haloperidol (0.5 mg/kg) increases latency to paw withdrawal in mouse models of capsaicin- but not force-induced mechanical hypersensitivity.