Taurocholic Acid 3-sulfate

Taurocholic acid 3-sulfate (TCA3S) 是共轭胆汁酸牛磺胆酸的代谢产物。

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500ug

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1mg

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Background

Taurocholic acid 3-sulfate (TCA3S) is a metabolite of the conjugated bile acid taurocholic acid.[1] Plasma levels of TCA3S are elevated in wild-type and Sortilin 1 (Sort1) knockout mice at 6 hours following bile duct ligation (BDL) and are further elevated in Sort1 knockout mice at 24 hours post-BDL.[2]

Reference：
[1]. Lefebvre, P., Cariou, B., Lien, F., et al. Role of bile acids and bile acid receptors in metabolic regulation. Physiol. Rev. 89(1), 147-191 (2009).
[2]. Li, J., Woolbright, B.L., Zhao, W., et al. Sortilin 1 loss-of-function protects against cholestatic liver injury by attenuating hepatic bile acid accumulation in bile duct ligated mice. Toxicol. Sci. 161(1), 34-47 (2018).