α-D-Glucose-1,6-bisphosphate (cyclohexyl ammonium salt hydrate)

α-D-Glucose-1,6-biphosphate 是葡萄糖的衍生物，用于研究碳水化合物代谢，特别是在 α-磷酸葡萄糖变位酶、β-磷酸葡萄糖变位酶以及 α- 和 β-己糖变位酶的鉴定、区分和表征方面。

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1mg

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货号: ajci74644
CAS: 71662-13-0
别名: Α-D-葡萄糖-1,6-二磷酸酯四(环己基铵)盐水合物,D-Glucose-1,6-diphosphate Glc-1,6-P2
分子式: C6H14O12P2?4C6H13N [XH2O]
分子量: 736.8
纯度: >98%
溶解度: 10mg/mL in PBS, pH 7.2
储存: Store at -20°C
库存: 现货

Background

α-D-Glucose-1,6-bisphosphate is a bis-phosphorylated derivative of α-D-glucose that has roles in carbohydrate metabolism.[1] It is the product of the reaction of glucose-1- or 6-phosphate with glucose-1,6-bisphosphate synthase (PGM2LI) in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate.[2] It is also a cofactor for the bacterial enzyme phosphopentomutase.[3],[4] α-D-Glucose-1,6-bisphosphate has been used in the study of carbohydrate metabolism. Reference：
[1]. Beitner, R. Regulation of carbohydrate metabolism by glucose 1,6-bisphosphate in extrahepatic tissues; comparison with fructose 2,6-bisphosphate. Int. J. Biochem. 22(6), 553-557 (1990).
[2]. Maliekal, P., Sokolova, T., Vertommen, D., et al. Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the α-D-phosphohexomutase family. J. Biol. Chem. 282(44), 31844-31851 (2007).
[3]. Moustafa, H.M.A., Zaghloul, T.I., and Zhang, Y.-H.P. A simple assay for determining activities of phosphopentomutase from a hyperthermophilic bacterium Thermotoga maritima. Anal. Biochem. 501, 75-81 (2016).
[4]. Panosian, T.D., Nannemann, D.P., Watkins, G.R., et al. Bacillus cereus phosphopentomutase is an alkaline phosphatase family member that exhibits an altered entry point into the catalytic cycle. J. Biol. Chem. 286(10), 8043-8054 (2011).