(-)-Neplanocin A

Irreversible SAH hydrolase inhibitor

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库存: 现货

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数量
500ug

￥4525.00

3620.00

- +
1mg

￥8625.00

6900.00

- +
5mg

￥35150.00

28120.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci74744
CAS: 72877-50-0
别名:
分子式: C11H13N5O3
分子量: 263.3
纯度: >98%
溶解度: DMF: 0.2 mg/ml,DMSO: 3 mg/ml,PBS (pH 7.2): 0.3 mg/ml
储存: Store at -20°C
库存: 现货

Background

S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine. The inhibition of SAH hydrolase causes the intracellular accumulation of SAH, elevating the ratio of SAH to S-adenosylmethionine (SAM) and inhibiting SAM-dependent methyltransferase. (-)-Neplanocin A potently and irreversibly inactivates SAH hydrolase (Ki = 8.39 nM). It has antitumor activity against mouse leukemia L1210 cells and broad-spectrum antiviral activity. Neplanocin A is more potent against vesicular stomatitis than the reversible SAH hydrolase inhibitor 3-deazaneplanocin (ID50 = 0.07 and 0.3 μg/ml, respectively).