Dantrolene sodium hemiheptahydrate (Dantrium) ia a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.
Dantrolene sodium hemiheptahydrate (Dantrium) ia a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.
Dantrolene sodium is a skeletal muscle relaxant, which inhibits intracellular Ca2+ release from the sarcoplasmic reticulum. Dantrolene sodium shows strong antioxidant activity in the linoleic acid emulsion system[2].
Dantrolene sodium (5 mg/kg) has a greater depressant action on the twitch contraction of the fast extensor digitorum longus (EDL) muscle than on the slow soleus (SOL) muscle[1].
[1] Leslie GC, et al. Br J Pharmacol. 1981, 72(4):665-72. [2] Büyükokuro?lu ME, et al. Pharmacol Res. 2001, 44(6):491-4.
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