Merbromin (Mercury dibromofluorescein disodium salt)

Merbromin (Mercurochrome), a xanthene dye and an antibacterial agent, is the first of a series of antiseptics that contained mercury, also is a mixed-type inhibitor of 3CLpro due to its ability of increasing the KM and decreasing the Kcat of 3CLpro.

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货号: ajce44582
CAS: 129-16-8
别名: 2,7-二溴-4-羟汞基荧光红双钠盐,Mercury dibromofluorescein disodium salt; ZP1
分子式: C20H10Br2HgNa2O6
分子量: 752.67
纯度: >98%
溶解度: Water : ≥ 50 mg/mL (66.43 mM);DMSO : 6.67 mg/mL (8.86 mM)
储存: Store at -20°C, protect from light
库存: 现货

Background

Merbromin strongly inhibites the proteolytic activity of 3CLpro which is a promising target for developing anti-SARS-CoV-2 drugs. Michaelis-Menten kinetic analysis shows that Merbromin is a mixed-type inhibitor of 3CLpro, indicating by its ability of increasing the KM and decreasing the Kcat of 3CLpro. And 3CLpro possessed two binding sites for Merbromin.[2]

[1] Chen J, et al. Biochem Biophys Res Commun. 2022 Feb 5;591:118-123. [2] Chen J, et al. Biochem Biophys Res Commun. 2022 Feb 5;591:118-123.