5-Hydroxymethyl-2-furancarboxylic acid

A major metabolite of 5-hydroxymethyl-2-furfural

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Background

5-Hydroxymethyl-2-furancarboxylic acid is the main metabolite of 5-hydroxymethyl-2-furfural, a product of acid-catalyzed degradation of sugars during the heating and storage of foods that influences taste and physiological functions in the body.¹ 5-Hydroxymethyl-2-furancarboxylic acid can be used as a building block in the enzymatic synthesis of macrocyclic oligoesters.²

1.J?bstl, D., Hus?y, T., Alexander, J., et al.Analysis of 5-hydroxymethyl-2-furoic acid (HMFA) the main metabolite of alimentary 5-hydroxymethyl-2-furfural (HMF) with HPLC and GC in urineFood Chem.123(3)814-818(2010) 2.Hirai, H., Naito, K., Hamasaki, T., et al.Syntheses of macrocyclic oligoesters from 5-hydroxymethyl-2-furancarboxylic acidMacromol. Chem. Phys.185(11)2347-2359(1984)