(S)-Willardiine ((-)-Willardiine)

(S)-Willardiine ((-)-Willardiine) 是一种有效的 AMPA/红藻氨酸受体激动剂，EC50 为 44.8 uM。

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
10mg

￥837.00

670.00

- +
50mg

￥3675.00

2940.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajce44666
CAS: 21416-43-3
别名: 尿嘧啶基丙氨酸; (-)-Willardiine
分子式: C7H9N3O4
分子量: 199.16
纯度: >98%
溶解度: DMSO : < 1 mg/mL (insoluble or slightly soluble)
储存: Store at -20°C
库存: 现货

Background

(S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM.IC50 value: 44.8 uM(EC50) [1]Target: AMPA/kainate receptor agonistin vitro: The (S)- but not (R)-isomers of willardiine and 5-bromowillardiine were potent agonists, producing rapidly but incompletely desensitizing responses [1]. At a concentration of 1.8 mM, Ca2+ inhibited the currents induced by 100 microM willardiine by approximately 50% [2].in vivo: In newborn mice (P5, histopathology at P10), local injection of the AMPA receptor agonist S-bromo-willardiine at day 5 after birth induced cortical damage and white matter damage, which was reduced in a dose-dependent manner by the AMPA receptor antagonists [3].

[1]. Patneau DK, et al. Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. J Neurosci. 1992 Feb;12(2):595-606. [2]. Fukushima T, et al. Calcium inhibits willardiine-induced responses in kainate receptor GluR6(Q)/KA-2. Neuroreport. 2001 Jan 22;12(1):163-7. [3]. Gressens P, et al. The effects of AMPA receptor antagonists in models of stroke and neurodegeneration. Eur J Pharmacol. 2005 Sep 5;519(1-2):58-67.