SPQ

A fluorescent chloride indicator

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50mg

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100mg

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货号: ajce44742
CAS: 83907-40-8
别名: 3-(6-甲氧基-1-喹啉基)丙磺酸内盐单水合物
分子式: C13H15NO4S
分子量: 281.33
纯度: >98%
溶解度: Water : 25 mg/mL (88.86 mM);DMSO : < 1 mg/mL (insoluble or slightly soluble)
储存: Store at -20°C
库存: 现货

Background

SPQ is a fluorescent chloride indicator.¹ Its fluorescence is rapidly quenched by chloride in vitro. It has been used to assess voltage-sensitive chloride transport in placental microvillus vesicles. It has also been used to continuously quantify intracellular calcium efflux induced by parathyroid hormone, forskolin , and phorbol 12-myristate 13-acetate in isolated human erythrocytes.² In addition, SPQ has been used to determine the type of ion conductance induced by the cystic fibrosis transmembrane conductance regulator (CFTR) in HEK293 cells expressing pTrial10-CRTR2.³ SPQ displays excitation maxima of 320 and 350 nm and an emission maximum of 445 nm.¹

1.Illsley, N.P., and Verkman, A.S.Membrane chloride transport measured using a chloride-sensitive fluorescent probeBiochemistry26(5)1215-1219(1987) 2.Soldati, L., Adamo, D., Spaventa, R., et al.Chloride fluxes activated by parathyroid hormone in human erythrocytesBiochem. Biophys. Res. Commun.269(2)470-473(2000) 3.MacVinish, L.J., Gill, D.R., Hyde, S.C., et al.Chloride secretion in the trachea of null cystic fibrosis mice: the effects of transfection with pTrial10-CFTR2J. Physiol.499(Pt. 3)677-687(1997)