Icariside I (Icarisid I)

A flavonoid glycoside with osteogenic and anticancer activities

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库存: 现货

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5mg

￥1612.00

1290.00

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10mg

￥2262.00

1810.00

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25mg

￥4487.00

3590.00

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Background

Icariside I is a flavonoid glycoside and an active metabolite of icariin that has been found in Epimedium and has osteogenic and anticancer activities.^1,2,3 It is formed from icariin in rats by intestinal microbiota.¹ It stimulates the proliferation and differentiation of isolated rat osteoblasts in a concentration-dependent manner.² Icariside I increases the cytotoxicity of adriamycin in multidrug-resistant MCF-7/adr breast cancer cells with an IC₅₀ value of 60.78 ?M.³

1.Angeloni, C., Barbalace, M.C., and Hrelia, S.Icariin and its metabolites as potential protective phytochemicals against alzheimer's diseaseFront. Pharmacol.10271(2019) 2.Liu, M., Xu, H., Ma, Y., et al.Osteoblasts proliferation and differentiation stimulating activities of the main components of Epimedii foliumPharmacogn. Mag.13(49)90-94(2017) 3.Liu, D.-F., Li, Y.-P., Ou, T.-M., et al.Synthesis and antimultidrug resistance evaluation of icariin and its derivativesBioorg. Med. Chem. Lett.19(15)4237-4240(2009)