Pinacidil monohydrate

A potassium channel opener

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库存: 现货

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5mg

￥437.00

350.00

- +
10mg

￥612.00

490.00

- +
25mg

￥1275.00

1020.00

- +

已选 0 种 0 瓶

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货号: ajce44776
CAS: 85371-64-8
别名: 吡那地尔一水合物; P-1134 monohydrate
分子式: C13H21N5O
分子量: 263.34
纯度: >98%
溶解度: 50 mg/ml in Ethanol (Need ultrasonic); 50 mg/ml in DMSO (Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

Pinacidil is a cyanoguanidine compound that acts as a potassium channel opener, activating the ATP-modulated potassium channels of guinea pig bladder and heart with K_i values of 104 and 251 nM, respectively.^1,2,3 It completely relaxes coronary artery rings preconstricted with serotonin .⁴ Through this mechanism, pinacidil causes vascular relaxation, decreases peripheral vascular resistance, and reduces hypertension in animals and humans.^5,6

1.Hermsmeyer, R.K.Pinacidil actions on ion channels in vascular muscleJ. Biomed. Sci.12(Suppl 2)S17-S22(1988) 2.Davis-Taber, R., Molinari, E.J., Altenbach, R.J., et al.[125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: Characterization and pharmacology of bindingMol. Pharmacol.64(1)143-153(2003) 3.Coghlan, M.J., Carroll, W.A., and Gopalakrishnan, M.Recent developments in the biology and medicinal chemistry of potassium channel modulators: Update from a decade of progressJ. Med. Chem.44(11)1627-1653(2001) 4.Gollasch, M., Bychkov, R., Ried, C., et al.Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cellsJ. Pharmacol. Exp. Ther.275(2)681-692(1995) 5.Cohen, M.L., and Kurz, K.D.Pinacidil-induced vascular relaxation: Comparison to other vasodilators and to classical mechanisms of vasodilationJ. Biomed. Sci.12(Suppl 2)S5-S9(1988) 6.Goldberg, M.R.Clinical pharmacology of pinacidil, a prototype for drugs that affect potassium channelsJ. Biomed. Sci.12(Suppl 2)S41-S47(1988)