Diatrizoic acid (Amidotrizoic acid)

Diatrizoic Acid (Amidotrizoic acid, Diatrizoate) is an organic, iodinated radiocontrast agent used in diagnostic radiography.

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100mg

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Background

Diatrizoic Acid (Amidotrizoic acid, Diatrizoate) is an organic, iodinated radiocontrast agent used in diagnostic radiography.

Protocol

Animal experiment:

Female Sprague-Dawley rats (200 to 250 grams) are housed in temperature and humidity controlled rooms with free access to food and water and maintained on a 12 h light/dark cycle. Rats are anesthetized by a 67.5 mg/kg ketamine, 3.5 mg/kg xylazine and 0.66 mg/kg acepromazine subcutaneous cocktail. While under anesthesia, rats are placed on a heating pad to maintain a body temperature of 37°C. Diatrizoic acid nanoparticle agglomerates (10 mg) is administered by intratracheal insufflation using a dry powder insufflator. At the end of the experiment, the rats are euthanized by isoflurane inhalation overdose followed by harvest of major organs[1].

参考文献:

[1]. El-Gendy N, et al. Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent. Int J Pharm. 2010 May 31;391(1-2):305-12.