Tigloidin (Tigloyl pseudotropine)

Tiglodin (Tigloyl pseudotropine) 是阿托品的类似物，具有抗胆碱能活性。

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库存: 现货

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1mg

￥1087.00

870.00

- +
5mg

￥2150.00

1720.00

- +
10mg

￥3625.00

2900.00

- +
20mg

￥6412.00

5130.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajce45126
CAS: 495-83-0
别名: 惕各酰托品因,Tigloyl pseudotropine; Tiglylpseudotropine; Tiglyssin
分子式: C13H21NO2
分子量: 223.31
纯度: >98%
溶解度: Soluble in DMSO
储存: Store at -20°C
库存: 现货

Background

Tigloidin is an analogue of atropine, with anticholinergic activity.

Tigloidine hydrobromide (20-60 mg/kg, i.p.) fails to protect the mice against the lethal effect of physostigmine, but at 100 mg/kg and above, it protects 80% of the animals against the lethal effect. Tigloidine markedly prevents tremor and salivation produced by tremorine at 80-100 mg/kg, but fails to prevent these effects in doses up to 40 mg/kg. Tigloidine (up to 100 mg/kg, i.p) does not significantly affects reserpine and tetrabenazine induced sedation and ptosis in mice. Tigloidine (25-50 mg/kg, i.p.) also fails to cause any behavioral changes in the cats[1].

[1]. Sanghvi I, et al. Pharmacology of a potential anti-Parkinson agent: tigloidine. Eur J Pharmacol. 1968 Oct;4(3):246-53.