DL-Homocysteine

An amino acid

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Background

DL-Homocysteine is a thiol-containing amino acid derived from methionine.¹ It inhibits vasodilation of precontracted isolated guinea pig pulmonary artery rings induced by acetylcholine (ACh) and enhances potassium chloride- and phenylephrine-induced contraction of isolated guinea pig pulmonary artery rings.² DL-Homocysteine (200 ?M) inhibits endothelium-dependent ACh-induced vasodilation in the vascular bed of isolated perfused rat pancreas.³ Elevated plasma levels of DL-homocysteine are positively correlated with occlusive arterial diseases and atherosclerosis.^1,2

1.Pushpakumar, S., Kundu, S., and Sen, U.Endothelial dysfunction: The link between homocysteine and hydrogen sulfideCurr. Med. Chem.21(32)3662-3672(2014) 2.Tasatargil, A., Sadan, G., and Karasu, E.Homocysteine-induced changes in vascular reactivity of guinea-pig pulmonary arteries: Role of the oxidative stress and poly (ADP-ribose) polymerase activationPulm. Pharmacol. Ther.20(3)265-272(2007) 3.Quéré, I., Hillaire-Buys, D., Brunschwig, C., et al.Effects of homocysteine on acetylcholine- and adenosine-induced vasodilatation of pancreatic vascular bed in ratsBr. J. Pharmacol.122(2)351-357(1997)