(+)-Cloprostenol (D-Cloprostenol)

A FP receptor agonist and potent luteolytic agent

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库存: 现货

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1mg

￥600.00

480.00

- +
5mg

￥2475.00

1980.00

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10mg

￥4212.00

3370.00

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25mg

￥8500.00

6800.00

- +

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货号: ajce45728
CAS: 54276-21-0
别名: (+)-氯前列烯醇,D-Cloprostenol
分子式: C22H29ClO6
分子量: 424.92
纯度: >98%
溶解度: DMSO: 100 mg/mL (235.34 mM); Ethanol: 50 mg/mL (117.67 mM)
储存: Store at -20°C
库存: 现货

Background

(+)-Cloprostenol is a synthetic analog of prostaglandin F_2α (PGF_2α). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. (+)-Cloprostenol is the optically active, 15(R) enantiomer of cloprostenol responsible for the majority of its biological activity. It is 200 times more potent than PGF_2α in terminating pregnancy when given subcutaneously at a daily dose of 0.125 μg/kg in rats and hamsters, without the side effects associated with PGF_2α.¹ (+)-Cloprostenol was also shown to be a potent inhibitor of rat adipose precursor differentiation in primary cultures with an IC₅₀ value of 3 pM.²

1.Dukes, M., Russell, W., and Walpole, A.L.Potent luteolytic agents related to prostaglandin F2αNature250(464)330-331(1974) 2.Serrero, G., and Lepak, N.M.Prostaglandin F2α receptor (FP receptor) agonists are potent adipose differentiation inhibitors for primary culture of adipocyte precursors in defined mediumBiochem. Biophys. Res. Commun.233(1)200-202(1997)